منابع مشابه
Spontaneous convulsions in Charles River Wistar rats.
Spontaneous clonic convulsions in the Charles River Wistar rat have been observed at an incidence of 1.5%. Females (2.3%) are more susceptible than males (0.7%). These convulsions are not seen in rats of less than approximately 16 weeks of age. Some animals have exhibited single convulsions whilst others have convulsed on numerous occasions. No histopathological abnormalities of the brain have ...
متن کاملSpontaneous neoplasms in control Wistar rats: a comparison of reviews.
Spontaneous neoplasms in 930 control Wistar rats from five carcinogenicity bioassays conducted between 1990 and 1995 were reviewed and compared with review findings in studies between 1980 and 1990. Mean survival at 104 weeks was 55% for males and 60% for females, similar to that of the previous review. A total of 1599 neoplasms was diagnosed in 361 (78%) male and 415 (89%) female rats; 1293 (8...
متن کاملFrequency of spontaneous tumors in Wistar rats in 30-months studies.
Tumors occurring in 450 male and 450 female control rats of the strain Wistar (BOR:WISW (SPF Cpb), breeder: Winkelmann, Borchen) employed in 9 control groups from 7 different 30-month studies were compiled on the basis of histopathology reports. 445 male and 448 female rats were evaluated. The remaining animals were unavailable due to autolysis. A total of 1211 tumors (565 in males, 646 in fema...
متن کاملAlloxanized Wistar Rats
The high rate of glycolysis in cancerous tissues, first described by Con in vivo (6) and by Warburg in vitro (@2),suggests that a considerable part of the energy supply for the neoplastic process is derived from the “anaerobic―phase of carbo hydrate catabolism. The low glycogen content characterizing a number of tumors (8—11, 13, I 7) may also indicate that the substrate for this process ...
متن کاملSpontaneous pineal body tumours (pinealomas) in Wistar rats; a histological and ultrastructural study.
The pathology of 5 cases of pinealomas in Wistar rats used in long-term toxicological studies is described both grossly, microscopically and ultrastructurally, together with a review of the related literature.
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1998
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339802600514